Catalytic Enantioselective Transformations Involving C–H Bond Cleavage by Transition-Metal Complexes

The development of new methods for the direct functionalization of unactivated C-H bonds is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic enantioselective functionalization of C-H bonds represents a highly atom- and step-economic approach toward the generation of structural complexity. However, as a result of their ubiquity and low reactivity, controlling both the chemo- and stereoselectivity of such processes constitutes a significant challenge. Herein we comprehensively review all asymmetric transition-metal-catalyzed methodologies that are believed to proceed via an inner-sphere-type mechanism, with an emphasis on the nature of stereochemistry generation.…

• NS
  National Science Foundation
• ÉP
  École Polytechnique Fédérale de Lausanne

  Award: 665667
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

  Award: 157741
• HM
  H2020 Marie Skłodowska-Curie Actions

  Award: 665667