articleThe Journal of Experimental MedicineFeb 23, 2017HYBRID OA

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

DÖDaniel ÖhlundAHAbram Handly-SantanaGBGiulia BiffiEEEla ElyadaASAna S. Almeida

Cold Spring Harbor Laboratory · Lustgarten Foundation · +10 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease progression and therapeutic response in pancreatic ductal adenocarcinoma (PDA). However, it is unknown whether CAFs uniformly carry out these tasks or if subtypes of CAFs with distinct phenotypes in PDA exist. We identified a CAF subpopulation with elevated expression of α-smooth muscle actin (αSMA) located immediately adjacent to neoplastic cells in mouse and human PDA tissue. We recapitulated this finding in co-cultures of murine PSCs and PDA organoids, and demonstrated that organoid-activated CAFs produced desmoplastic stroma. The co-cultures showed…

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23

Topics & keywords

Topics
Keywords
  • Myofibroblast
  • Stroma
  • Cancer-Associated Fibroblasts
  • Pancreatic cancer
  • Biology
  • Phenotype
  • Organoid
  • Cancer research
UN Sustainable Development Goals
  • Good health and well-being
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