Genetic Basis of Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and despite cure rates exceeding 90% in children, it remains an important cause of morbidity and mortality in children and adults. The past decade has been marked by extraordinary advances into the genetic basis of leukemogenesis and treatment responsiveness in ALL. Both B-cell and T-cell ALL comprise multiple subtypes harboring distinct constellations of somatic structural DNA rearrangements and sequence mutations that commonly perturb lymphoid development, cytokine receptors, kinase and Ras signaling, tumor suppression, and chromatin modification. Recent studies have helped to understand the genetic basis of clonal evolution and relapse…

• AA
  American Association for Cancer Research
• PC
  Pew Charitable Trusts
• AS
  American Society of Hematology
• AL
  Alex's Lemonade Stand Foundation for Childhood Cancer
• LA
  Leukemia and Lymphoma Society
• SB
  St. Baldrick's Foundation
• LT
  Lady Tata Memorial Trust
• AL
  American Lebanese Syrian Associated Charities
• CO
  Children’s Oncology Group
• NI
  National Institutes of Health
• SU
  Stand Up To Cancer
• MR
  Medical Research Council
• NH
  National Health and Medical Research Council
• NC
  National Cancer Institute