reviewFrontiers in Cell and Developmental BiologyMar 7, 2017GOLD OA

CD44: A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer Cells

LTLinda T. SenbanjoMAMeenakshi A. Chellaiah

University of Maryland, Baltimore

PubMed
Indexed incrossrefdoajpubmed

Abstract

CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with appropriate extracellular matrix ligands promotes the migration and invasion processes involved in metastases. It was originally identified as a receptor for hyaluronan or hyaluronic acid and later to several other ligands including, osteopontin (OPN), collagens, and matrix metalloproteinases. CD44 has also been identified as a marker for stem cells of several types. Beside standard CD44 (sCD44), variant (vCD44) isoforms of CD44 have been shown to be created by alternate splicing of the mRNA in several cancer. Addition of new exons into the…

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Topics & keywords

Topics
Keywords
  • CD44
  • Metastasis
  • Cancer research
  • Cancer stem cell
  • Cancer cell
  • Biology
  • Extracellular matrix
  • Cancer
UN Sustainable Development Goals
  • Good health and well-being
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