TGF-β Family Signaling in Tumor Suppression and Cancer Progression
Institució Catalana de Recerca i Estudis Avançats · Vall d'Hebron Institut de Recerca · +3 more institutions
Abstract
Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the cellular context and its integration with other signaling pathways. In cancer, the pleiotropic reaction to TGF-β leads to a diverse and varied set of gene responses that range from cytostatic and apoptotic tumor-suppressive ones in early stage tumors, to proliferative, invasive, angiogenic, and oncogenic ones in advanced cancer. Here, we review the knowledge accumulated about the molecular mechanisms involved in the dual response to TGF-β in cancer, and how tumor cells evolve to evade the tumor-suppressive responses of this signaling pathway and then hijack the signal, converting it into an oncogenic factor. Only…
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- References
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Authors
2Topics & keywords
- Biology
- Signal transduction
- Transforming growth factor
- Cancer research
- Cancer
- Context (archaeology)
- Transforming growth factor beta
- Tumor progression
- Good health and well-being