Freeze for action: neurobiological mechanisms in animal and human freezing

Upon increasing levels of threat, animals activate qualitatively different defensive modes, including freezing and active fight-or-flight reactions. Whereas freezing is a form of behavioural inhibition accompanied by parasympathetically dominated heart rate deceleration, fight-or-flight reactions are associated with sympathetically driven heart rate acceleration. Despite the potential relevance of freezing for human stress-coping, its phenomenology and neurobiological underpinnings remain largely unexplored in humans. Studies in rodents have shown that freezing depends on amygdala projections to the brainstem (periaqueductal grey). Recent neuroimaging studies in humans have indicated that similar brain regions…

• NO
  Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Award: VICI / 453-12-001
• ER
  European Research Council

  Award: ERC_StG / 2012_313749