Cell-Free DNA and Active Rejection in Kidney Allografts
University of Pennsylvania · Cleveland Clinic · +15 more institutions
Abstract
Histologic analysis of the allograft biopsy specimen is the standard method used to differentiate rejection from other injury in kidney transplants. Donor-derived cell-free DNA (dd-cfDNA) is a noninvasive test of allograft injury that may enable more frequent, quantitative, and safer assessment of allograft rejection and injury status. To investigate this possibility, we prospectively collected blood specimens at scheduled intervals and at the time of clinically indicated biopsies. In 102 kidney recipients, we measured plasma levels of dd-cfDNA and correlated the levels with allograft rejection status ascertained by histology in 107 biopsy specimens. The dd-cfDNA level discriminated between biopsy specimens…
Citation impact
- FWCI
- 31.15
- Percentile
- 100%
- References
- 21
Authors
23Topics & keywords
- Medicine
- Biopsy
- Receiver operating characteristic
- Kidney transplantation
- Cutoff
- Cell-free fetal DNA
- Urology
- Confidence interval
- Reduced inequalities