articleProceedings of the National Academy of SciencesMar 6, 2017BRONZE OA

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

YSYu Shrike ZhangJAJulio AlemanSRSu Ryon ShinTKTuğba KiliçDJDuck Jin Kim

Brigham and Women's Hospital · Harvard University · +19 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Organ-on-a-chip systems are miniaturized microfluidic 3D human tissue and organ models designed to recapitulate the important biological and physiological parameters of their in vivo counterparts. They have recently emerged as a viable platform for personalized medicine and drug screening. These in vitro models, featuring biomimetic compositions, architectures, and functions, are expected to replace the conventional planar, static cell cultures and bridge the gap between the currently used preclinical animal models and the human body. Multiple organoid models may be further connected together through the microfluidics in a similar manner in which they are arranged in vivo, providing the capability to analyze…

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Topics & keywords

Topics
Keywords
  • Microfluidics
  • Modular design
  • Organ-on-a-chip
  • Computer science
  • Organoid
  • Microfluidic chip
  • Vibratome
  • Embedded system
UN Sustainable Development Goals
  • Good health and well-being
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