Focal Segmental Glomerulosclerosis
National Institutes of Health · Johns Hopkins University · +1 more institution
Abstract
Focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness to immunosuppressive therapy and a risk of recurrence after kidney transplant–important disease characteristics. In contrast, adaptive FSGS is associated with excessive nephron workload due to increased body size, reduced nephron capacity, or single glomerular hyperfiltration associated with certain diseases. Additional etiologies are now recognized as drivers of FSGS: high-penetrance genetic FSGS due to mutations in one of nearly 40 genes, virus-associated FSGS, and medication-associated FSGS. Emerging data support the identification of a sixth…
Citation impact
- FWCI
- 22.80
- Percentile
- 100%
- References
- 152
Authors
2- AZAvi Z. RosenbergCorresponding
National Institutes of Health, Johns Hopkins University, National Institute of Diabetes and Digestive and Kidney Diseases
- JBJeffrey B. KoppCorresponding
National Institutes of Health, Johns Hopkins University, National Institute of Diabetes and Digestive and Kidney Diseases
Topics & keywords
- Medicine
- Focal segmental glomerulosclerosis
- Internal medicine
- Glomerulonephritis
- Kidney
- Good health and well-being