articleJournal of the American Chemical SocietyMar 3, 2017Closed access

Targeted Drug Delivery in Covalent Organic Nanosheets (CONs) via Sequential Postsynthetic Modification

SMShouvik MitraHSHimadri Sekhar SasmalTKTanay KunduSKSharath KandambethKIKavya Illath

National Chemical Laboratory · Academy of Scientific and Innovative Research · +2 more institutions

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Abstract

Covalent organic nanosheets (CONs) have emerged as a new class of functional two-dimensional (2D) porous organic polymeric materials with a high accessible surface, diverse functionality, and chemical stability. They could become versatile candidates for targeted drug delivery. Despite their many advantages, there are limitations to their use for target specific drug delivery. We anticipated that these drawbacks could be overturned by judicious postsynthetic modification steps to use CONs for targeted drug delivery. The postsynthetic modification would not only produce the desired functionality, it would also help to exfoliate to CONs as well. In order to meet this requirement, we have developed a facile,…

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Authors

7

Topics & keywords

Topics
Keywords
  • Chemistry
  • Surface modification
  • Drug delivery
  • Nanotechnology
  • Covalent bond
  • Targeted drug delivery
  • Combinatorial chemistry
  • Chemical modification
UN Sustainable Development Goals
  • Good health and well-being
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