reviewJournal of Clinical InvestigationMar 1, 2017BRONZE OA

The role of the complement system in cancer

VAVahid Afshar‐Kharghan
PubMed
Indexed incrossrefdoajpubmed

Abstract

In addition to being a component of innate immunity and an ancient defense mechanism against invading pathogens, complement activation also participates in the adaptive immune response, inflammation, hemostasis, embryogenesis, and organ repair and development. Activation of the complement system via classical, lectin, or alternative pathways generates anaphylatoxins (C3a and C5a) and membrane attack complex (C5b-9) and opsonizes targeted cells. Complement activation end products and their receptors mediate cell-cell interactions that regulate several biological functions in the extravascular tissue. Signaling of anaphylatoxin receptors or assembly of membrane attack complex promotes cell dedifferentiation,…

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553
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100%
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Authors

1

Topics & keywords

Topics
Keywords
  • Anaphylatoxin
  • Complement system
  • Cell biology
  • Classical complement pathway
  • Complement membrane attack complex
  • Biology
  • Alternative complement pathway
  • Immune system
UN Sustainable Development Goals
  • Good health and well-being
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