The Essential Role of Bond Energetics in C–H Activation/Functionalization

The most fundamental concepts in chemistry are structure, energetics, reactivity and their inter-relationships, which are indispensable for promoting chemistry into a rational science. In this regard, bond energy, the intrinsic determinant directly related to structure and reactivity, should be most essential in serving as a quantitative basis for the design and understanding of organic transformations. Although C-H activation/functionalization have drawn tremendous research attention and flourished during the past decades, understanding the governing rules of bond energetics in these processes is still fragmentary and seems applicable only to limited cases, such as metal-oxo-mediated hydrogen atom…

• NN
  National Natural Science Foundation of China

  Awards: 21672124, 21172118, 21172112, 21390401, 20832004, 20902091, 21402099
• TU
  Tsinghua University
• NU
  Nankai University