Targeting noncoding RNAs in disease

Many RNA species have been identified as important players in the development of chronic diseases, including cancer. Over the past decade, numerous studies have highlighted how regulatory RNAs such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) play crucial roles in the development of a disease state. It is clear that the aberrant expression of miRNAs promotes tumor initiation and progression, is linked with cardiac dysfunction, allows for the improper physiological response in maintaining glucose and insulin levels, and can prevent the appropriate integration of neuronal networks, resulting in neurodegenerative disorders. Because of this, there has been a major effort to therapeutically target these…

• NS
  National Science Foundation

  Award: CA196530
• YU
  Yale University

  Award: P50 CA196530
• BC
  Bowdoin College
• NI
  National Institutes of Health

  Awards: R01 CA157749, CA196530, P50 CA196530, R01 CA131301
• UA
  University at Albany