articleMolecular PsychiatryMay 2, 2017HYBRID OA

Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group

FTfor the ENIGMA Bipolar Disorder Working GroupDPDerrek P. HibarLTLars T. WestlyeNTNhat Trung DoanNJNeda Jahanshad

University of Southern California · Janssen (United States) · +70 more institutions

PubMed
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Abstract

Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed the largest study to date of cortical gray matter thickness and surface area measures from brain magnetic resonance imaging scans of 6503 individuals including 1837 unrelated adults with BD and 2582 unrelated healthy controls for group differences while also examining the effects of commonly prescribed medications, age of illness onset, history of psychosis, mood state, age and sex differences on cortical regions. In BD, cortical gray matter was thinner in…

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Topics & keywords

Topics
Keywords
  • Bipolar disorder
  • Psychology
  • Neuroscience
  • Psychiatry
  • Medicine
  • Cognition
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