Antimalarial Drug Resistance: A Threat to Malaria Elimination
Institut Pasteur du Cambodge · Mahidol Oxford Tropical Medicine Research Unit
Abstract
Increasing antimalarial drug resistance once again threatens effective antimalarial drug treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are first-line treatment for uncomplicated falciparum malaria in all endemic countries, yet partial resistance to artemisinins has emerged in the Greater Mekong Subregion. Concomitant emergence of partner drug resistance is now causing high ACT treatment failure rates in several areas. Genetic markers for artemisinin resistance and several of the partner drugs have been established, greatly facilitating surveillance. Single point mutations in the gene coding for the Kelch propeller domain of the K13 protein strongly correlate with…
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2Topics & keywords
- Malaria
- Tropical medicine
- Epidemiology
- Drug resistance
- Medicine
- Unit (ring theory)
- Environmental health
- Traditional medicine
- Good health and well-being