Benchmarking of participant-level confound regression strategies for the control of motion artifact in studies of functional connectivity

Since initial reports regarding the impact of motion artifact on measures of functional connectivity, there has been a proliferation of participant-level confound regression methods to limit its impact. However, many of the most commonly used techniques have not been systematically evaluated using a broad range of outcome measures. Here, we provide a systematic evaluation of 14 participant-level confound regression methods in 393 youths. Specifically, we compare methods according to four benchmarks, including the residual relationship between motion and connectivity, distance-dependent effects of motion on connectivity, network identifiability, and additional degrees of freedom lost in confound regression. Our…

• NI
  National Institute of Mental Health

  Awards: MH089983, R21MH106799, R01MH107703, MH089924, R01MH107235, R01NS089630, R01-DC-009209-11
• NI
  National Institute of Child Health and Human Development

  Award: R01HD086888-01