articlePlant Biotechnology JournalMar 29, 2017GOLD OA

Engineering canker‐resistant plants through CRISPR /Cas9‐targeted editing of the susceptibility gene Cs LOB 1 promoter in citrus

Southwest University · Citrus Research Institute · +1 more institution

PubMed
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Abstract

Summary Citrus canker, caused by Xanthomonas citri subsp. citri ( Xcc ), is severely damaging to the global citrus industry. Targeted editing of host disease‐susceptibility genes represents an interesting and potentially durable alternative in plant breeding for resistance. Here, we report improvement of citrus canker resistance through CRISPR /Cas9‐targeted modification of the susceptibility gene Cs LOB 1 promoter in citrus. Wanjincheng orange ( Citrus sinensis Osbeck) harbours at least three copies of the Cs LOB 1 G allele and one copy of the Cs LOB 1 − allele. The promoter of both alleles contains the effector binding element ( EBE P thA4 ), which is recognized by the main effector PthA4 of Xcc to activate…

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