articleBriefings in BioinformaticsJan 30, 2017BRONZE OA

Circular RNA identification based on multiple seed matching

YGYuan GaoJZJinyang ZhangFZFangqing Zhao

University of Chinese Academy of Sciences · Chinese Academy of Sciences · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Computational detection methods have been widely used in studies on the biogenesis and the function of circular RNAs (circRNAs). However, all of the existing tools showed disadvantages on certain aspects of circRNA detection. Here, we propose an improved multithreading detection tool, CIRI2, which used an adapted maximum likelihood estimation based on multiple seed matching to identify back-spliced junction reads and to filter false positives derived from repetitive sequences and mapping errors. We established objective assessment criteria based on real data from RNase R-treated samples and systematically compared 10 circular detection tools, which demonstrated that CIRI2 outperformed its previous version CIRI…

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782
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3

Topics & keywords

Topics
Keywords
  • False positive paradox
  • Computer science
  • Circular RNA
  • Identification (biology)
  • Reliability (semiconductor)
  • Sensitivity (control systems)
  • Multithreading
  • Matching (statistics)
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