Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action
Central University of Rajasthan · Fondazione Santa Lucia · +1 more institution
Abstract
) values available in the literature so far. Different mode of action of anti biofilm molecules addressed here are inhibition via interference in the quorum sensing pathways, adhesion mechanism, disruption of extracellular DNA, protein, lipopolysaccharides, exopolysaccharides and secondary messengers involved in various signaling pathways. From this study, we conclude that the molecules considered here might be used to treat biofilm-associated infections after significant structural modifications, thereby investigating its effective delivery in the host. It should also be ensured that minimum effective concentration of these molecules must be capable of eradicating biofilm infections with maximum potency…
Citation impact
- FWCI
- 29.94
- Percentile
- 100%
- References
- 276
Authors
4Topics & keywords
- Biofilm
- Quorum sensing
- Microbiology
- Extracellular polymeric substance
- Biology
- Bacteria
- Antibiotics
- Minimum bactericidal concentration
- Good health and well-being