m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

Cui, Qi; Shi, Hailing; Ye, Peng; Li, Li; Qu, Qiuhao; Sun, Guoqiang; Sun, Guihua; Lu, Zhike; Huang, Yue; Yang, Cai‐Guang; Riggs, Arthur D.; He, Chuan; Shi, Yanhong

doi:10.1016/j.celrep.2017.02.059

articleCell ReportsMar 1, 2017GOLD OA

m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

QCQi Cui HSHailing Shi PYPeng Ye LLLi Li QQQiuhao Qu

City of Hope · Beckman Research Institute · +4 more institutions

Indexed incrossrefdoaj

Abstract

RNA modifications play critical roles in important biological processes. However, the functions of N6-methyladenosine (m6A) mRNA modification in cancer biology and cancer stem cells remain largely unknown. Here, we show that m6A mRNA modification is critical for glioblastoma stem cell (GSC) self-renewal and tumorigenesis. Knockdown of METTL3 or METTL14, key components of the RNA methyltransferase complex, dramatically promotes human GSC growth, self-renewal, and tumorigenesis. In contrast, overexpression of METTL3 or inhibition of the RNA demethylase FTO suppresses GSC growth and self-renewal. Moreover, inhibition of FTO suppresses tumor progression and prolongs lifespan of GSC-grafted mice substantially. m6A…

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Topics & keywords

Topics

Keywords

Glioblastoma
Methylation
Carcinogenesis
Stem cell
RNA
Biology
Cancer research
DNA methylation

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