Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration
Foundation for Biomedical Research · Foundation for Biomedical Research and Innovation · +7 more institutions
Abstract
We assessed the feasibility of transplanting a sheet of retinal pigment epithelial (RPE) cells differentiated from induced pluripotent stem cells (iPSCs) in a patient with neovascular age-related macular degeneration. The iPSCs were generated from skin fibroblasts obtained from two patients with advanced neovascular age-related macular degeneration and were differentiated into RPE cells. The RPE cells and the iPSCs from which they were derived were subject to extensive testing. A surgery that included the removal of the neovascular membrane and transplantation of the autologous iPSC-derived RPE cell sheet under the retina was performed in one of the patients. At 1 year after surgery, the transplanted sheet…
Citation impact
- FWCI
- 75.13
- Percentile
- 100%
- References
- 30
Authors
39- MMMichiko MandaiCorresponding
Foundation for Biomedical Research, Foundation for Biomedical Research and Innovation
- AWAkira Watanabe
Foundation for Biomedical Research, Gladstone Institutes
- YKYasuo Kurimoto
Foundation for Biomedical Research, Kobe City Medical Center General Hospital, Foundation for Biomedical Research and Innovation
- YHYasuhiko Hirami
Foundation for Biomedical Research, Kobe City Medical Center General Hospital, Foundation for Biomedical Research and Innovation
- CMChikako Morinaga
Foundation for Biomedical Research
Topics & keywords
- Macular degeneration
- Medicine
- Induced pluripotent stem cell
- Ophthalmology
- Retinal
- Transplantation
- Retina
- Visual acuity
- Good health and well-being