articleScientific ReportsJul 16, 2014GOLD OA

Correction: Corrigendum: Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo

Pulmonary Associates

Indexed incrossrefdoaj

Abstract

To determine the efficacy of potential cystic fibrosis (CF) therapies we have developed a novel mucociliary transit (MCT) measurement that uses synchrotron phase contrast X-ray imaging (PCXI) to non-invasively measure the transit rate of individual micron-sized particles deposited into the airways of live mice. The aim of this study was to image changes in MCT produced by a rehydrating treatment based on hypertonic saline (HS), a current CF clinical treatment. Live mice received HS containing a long acting epithelial sodium channel blocker (P308); isotonic saline; or no treatment, using a nebuliser integrated within a small-animal ventilator circuit. Marker particle motion was tracked for 20 minutes using…

Citation impact

735
total citations
FWCI
65.30
Percentile
100%
References
0
Citations per year

Authors

8

Topics & keywords

Keywords
  • In vivo
  • Cystic fibrosis
  • Medicine
  • Mucociliary clearance
  • Hypertonic saline
  • Isotonic
  • Clinical trial
  • Saline
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.