The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace
Cook County Health and Hospitals System · Rush University Medical Center
Abstract
Carbapenem-resistant Enterobacteriaceae (CRE) are a serious public health threat. Infections due to these organisms are associated with significant morbidity and mortality. Mechanisms of drug resistance in gram-negative bacteria (GNB) are numerous; β-lactamase genes carried on mobile genetic elements are a key mechanism for the rapid spread of antibiotic-resistant GNB worldwide. Transmissible carbapenem-resistance in Enterobacteriaceae has been recognized for the last 2 decades, but global dissemination of carbapenemase-producing Enterobacteriaceae (CPE) is a more recent problem that, once initiated, has been occurring at an alarming pace. In this article, we discuss the evolution of CRE, with a focus on the…
Citation impact
- FWCI
- 43.20
- Percentile
- 100%
- References
- 97
Authors
2Topics & keywords
- Carbapenem-resistant enterobacteriaceae
- Enterobacteriaceae
- Klebsiella pneumoniae
- Microbiology
- Biology
- Pandemic
- Antibiotic resistance
- Epidemiology
- Good health and well-being