Engrams and circuits crucial for systems consolidation of a memory

Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks for permanent storage. However, the engrams and circuits that support neocortical memory consolidation have thus far been unknown. We found that neocortical prefrontal memory engram cells, which are critical for remote contextual fear memory, were rapidly generated during initial learning through inputs from both the hippocampal-entorhinal cortex network and the basolateral amygdala. After their generation, the prefrontal engram cells, with support from hippocampal memory engram cells, became functionally mature with time. Whereas hippocampal engram…

• HH
  Howard Hughes Medical Institute

  Award: award304794
• JF
  JPB Foundation

  Award: award304797
• R
  RIKEN

  Award: award304795
• RB
  RIKEN Brain Science Institute