SynergyFinder: a web application for analyzing drug combination dose–response matrix data
University of Helsinki · Institute for Molecular Medicine Finland · +1 more institution
Abstract
SUMMARY: Rational design of drug combinations has become a promising strategy to tackle the drug sensitivity and resistance problem in cancer treatment. To systematically evaluate the pre-clinical significance of pairwise drug combinations, functional screening assays that probe combination effects in a dose-response matrix assay are commonly used. To facilitate the analysis of such drug combination experiments, we implemented a web application that uses key functions of R-package SynergyFinder, and provides not only the flexibility of using multiple synergy scoring models, but also a user-friendly interface for visualizing the drug combination landscapes in an interactive manner. AVAILABILITY AND…
Citation impact
- FWCI
- 44.31
- Percentile
- 100%
- References
- 12
Authors
4- AIAleksandr Ianevski
University of Helsinki, Institute for Molecular Medicine Finland
- LHLiye He
University of Helsinki, Institute for Molecular Medicine Finland
- TATero Aittokallio
University of Helsinki, University of Turku, Institute for Molecular Medicine Finland
- JTJing TangCorresponding
University of Helsinki, University of Turku, Institute for Molecular Medicine Finland
Topics & keywords
- Computer science
- Bioconductor
- Pairwise comparison
- R package
- Flexibility (engineering)
- Source code
- Key (lock)
- Web application
- Good health and well-being