reviewClinical Pharmacology & TherapeuticsApr 5, 2017HYBRID OA

Worldwide Distribution of Cytochrome P450 Alleles: A Meta‐analysis of Population‐scale Sequencing Projects

YZYitian ZhouMIMagnus Ingelman‐SundbergVMVolker M. Lauschke

Karolinska Institutet

PubMed
Indexed incrossrefpubmed

Abstract

Genetic polymorphisms in cytochrome P450 (CYP) genes can result in altered metabolic activity toward a plethora of clinically important medications. Thus, single nucleotide variants and copy number variations in CYP genes are major determinants of drug pharmacokinetics and toxicity and constitute pharmacogenetic biomarkers for drug dosing, efficacy, and safety. Strikingly, the distribution of CYP alleles differs considerably between populations with important implications for personalized drug therapy and healthcare programs. To provide a global distribution map of CYP alleles with clinical importance, we integrated whole-genome and exome sequencing data from 56,945 unrelated individuals of five major human…

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Authors

3

Topics & keywords

Topics
Keywords
  • Biology
  • Pharmacogenetics
  • Genetics
  • Population
  • Allele
  • Exome
  • Pharmacogenomics
  • Exome sequencing
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