Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia
Chinese Academy of Sciences · Shanghai Institute of Ceramics · +1 more institution
Abstract
Hypoxia development in tumor is closely associated with its increased aggressiveness and strong resistance to therapy, leading to the poor prognosis in several cancer types. Clinically, invasive oxygen microelectrode and high dosage radiotherapy are often utilized to accurately detect and effectively fight hypoxia. Recently, however, there has been a surge of interdisciplinary research aiming at developing functional molecules and nanomaterials that can be used to noninvasively image and efficiently treat hypoxic tumors. In this review, we will provide an overview of the reports published to date on the imaging and therapy of hypoxic tumors. First, we will present the design concepts and engineering of various…
Citation impact
- FWCI
- 47.88
- Percentile
- 100%
- References
- 609
Authors
3Topics & keywords
- Hypoxia (environmental)
- Tumor hypoxia
- Radiation therapy
- Positron emission tomography
- Cancer therapy
- Magnetic resonance imaging
- Nanotechnology
- Chemistry