reviewEBioMedicineApr 11, 2017GOLD OA

Cellular Senescence: A Translational Perspective

JLJames L. KirklandTTTamar Tchkonia

Mayo Clinic in Florida

PubMed
Indexed incrossrefdoajpubmed

Abstract

Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance, and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated secretory phenotype (SASP). Senescent cells accumulate in various tissues with aging and at sites of pathogenesis in many chronic diseases and conditions. The SASP can contribute to senescence-related inflammation, metabolic dysregulation, stem cell dysfunction, aging phenotypes, chronic diseases, geriatric syndromes, and loss of resilience. Delaying senescent cell accumulation or reducing senescent cell burden is associated with delay, prevention, or alleviation of multiple senescence-associated conditions. We used a…

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989
total citations
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48.64
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100%
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69
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Authors

2

Topics & keywords

Topics
Keywords
  • Senescence
  • Phenotype
  • Biology
  • Inflammation
  • Autophagy
  • Cell biology
  • Stem cell
  • Cell
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