Emerging roles of lipid metabolism in cancer metastasis
Central South University · Xiangya Hospital Central South University
Abstract
Cancer cells frequently display fundamentally altered cellular metabolism, which provides the biochemical foundation and directly contributes to tumorigenicity and malignancy. Rewiring of metabolic programmes, such as aerobic glycolysis and increased glutamine metabolism, are crucial for cancer cells to shed from a primary tumor, overcome the nutrient and energy deficit, and eventually survive and form metastases. However, the role of lipid metabolism that confers the aggressive properties of malignant cancers remains obscure. The present review is focused on key enzymes in lipid metabolism associated with metastatic disease pathogenesis. We also address the function of an important membrane structure-lipid…
Citation impact
- FWCI
- 16.13
- Percentile
- 100%
- References
- 113
Authors
7- XLXiangjian LuoCorresponding
Central South University, Xiangya Hospital Central South University
- CCCan Cheng
Central South University, Xiangya Hospital Central South University
- ZTZheqiong Tan
Central South University, Xiangya Hospital Central South University
- NLNamei Li
Xiangya Hospital Central South University, Central South University
- MTMin Tang
Xiangya Hospital Central South University, Central South University
Topics & keywords
- Lipid metabolism
- Biology
- Metastasis
- Cancer
- Cancer cell
- Cancer research
- Anaerobic glycolysis
- Warburg effect
- Good health and well-being