reviewPolymersApr 12, 2017GOLD OA

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

MRMuhammad RizwanRYRosiyah YahyaAHAziz HassanMYMuhammad YarADAhmad Danial Azzahari

University of Malaya · COMSATS University Islamabad · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than the development of novel drugs which involve much expense and time. The efficacy of drugs is affected by a number of factors such as their low aqueous solubility, unequal absorption along the gastrointestinal (GI) tract, risk of degradation in the acidic milieu of the stomach, low permeation of the drugs in the upper GI tract, systematic side effects, etc. This review aims to enlighten readers on the role of pH sensitive hydrogels in drug delivery, their mechanism of action, swelling, and drug release as a function of pH change along the GI tract. The basis for the selection of materials, their structural…

Citation impact

790
total citations
FWCI
14.03
Percentile
100%
References
162
Citations per year

Authors

8

Topics & keywords

Topics
Keywords
  • Swelling
  • Self-healing hydrogels
  • Drug
  • Drug delivery
  • Chemistry
  • Pharmacology
  • Solubility
  • Materials science
UN Sustainable Development Goals
  • Good health and well-being
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