Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

Park, Thomas J.; Reznick, Jane; Peterson, Bethany L.; Blass, Gregory; Omerbašić, Damir; Bennett, Nigel C.; Kuich, P. Henning J. L.; Zasada, Christin; Browe, Brigitte M.; Hamann, Wiebke; Applegate, Daniel T.; Radkë, Michaël; Kosten, Tetiana; Lutermann, Heike; Gavaghan, Victoria; Eigenbrod, Ole; Bégay, Valérie; Amoroso, Vince G.; Govind, Vidya; Minshall, Richard D.; Smith, Ewan St. John; Larson, John; Gotthardt, Michael; Kempa, Stefan; Lewin, Gary R.

doi:10.1126/science.aab3896

articleScienceApr 20, 2017GREEN OA

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

TJThomas J. Park JRJane Reznick BLBethany L. Peterson GBGregory Blass DODamir Omerbašić

University of Illinois Chicago · Max Delbrück Center · +4 more institutions

PubMed

Indexed incrossrefdatacitepubmed

Abstract

) social and subterranean lifestyle generates a hypoxic niche. Under experimental conditions, naked mole-rats tolerate hours of extreme hypoxia and survive 18 minutes of total oxygen deprivation (anoxia) without apparent injury. During anoxia, the naked mole-rat switches to anaerobic metabolism fueled by fructose, which is actively accumulated and metabolized to lactate in the brain. Global expression of the GLUT5 fructose transporter and high levels of ketohexokinase were identified as molecular signatures of fructose metabolism. Fructose-driven glycolytic respiration in naked mole-rat tissues avoids feedback inhibition of glycolysis via phosphofructokinase, supporting viability. The metabolic rewiring of…

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Topics & keywords

Topics

Keywords

Anaerobic glycolysis
Fructose
Glycolysis
Anaerobic exercise
Rodent
Hypoxia (environmental)
Biology
Mole

UN Sustainable Development Goals

Life in Land

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