reviewInternational Journal of NanomedicineApr 1, 2017GOLD OA

Protein corona: a new approach for nanomedicine design

VHVan Hong NguyenBLBeom‐Jin Lee

Ajou University

PubMed
Indexed incrossrefdoajpubmed

Abstract

After administration of nanoparticle (NP) into biological fluids, an NP-protein complex is formed, which represents the "true identity" of NP in our body. Hence, protein-NP interaction should be carefully investigated to predict and control the fate of NPs or drug-loaded NPs, including systemic circulation, biodistribution, and bioavailability. In this review, we mainly focus on the formation of protein corona and its potential applications in pharmaceutical sciences such as prediction modeling based on NP-adsorbed proteins, usage of active proteins for modifying NP to achieve toxicity reduction, circulation time enhancement, and targeting effect. Validated correlative models for NP biological responses mainly…

Citation impact

623
total citations
FWCI
29.81
Percentile
100%
References
126
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Biodistribution
  • Nanomedicine
  • Drug delivery
  • Chemistry
  • Toxicity
  • Biophysics
  • Bioavailability
  • Drug
UN Sustainable Development Goals
  • Good health and well-being
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