Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

Thevaranjan, Netusha; Puchta, Alicja; Schulz, Christian; Naidoo, Avee; Szamosi, Jake C.; Verschoor, Chris P.; Loukov, Dessi; Schenck, L. Patrick; Jury, Jennifer; Foley, Kevin P.; Schertzer, Jonathan D.; Larché, Maggie; Davidson, Donald J.; Verdú, Elena F.; Surette, Michael G.; Bowdish, Dawn M. E.

doi:10.1016/j.chom.2017.03.002

letterCell Host & MicrobeApr 1, 2017HYBRID OA

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

NTNetusha Thevaranjan APAlicja Puchta CSChristian Schulz ANAvee Naidoo JCJake C. Szamosi

McMaster University · Population Health Research Institute · +4 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Levels of inflammatory mediators in circulation are known to increase with age, but the underlying cause of this age-associated inflammation is debated. We find that, when maintained under germ-free conditions, mice do not display an age-related increase in circulating pro-inflammatory cytokine levels. A higher proportion of germ-free mice live to 600 days than their conventional counterparts, and macrophages derived from aged germ-free mice maintain anti-microbial activity. Co-housing germ-free mice with old, but not young, conventionally raised mice increases pro-inflammatory cytokines in the blood. In tumor necrosis factor (TNF)-deficient mice, which are protected from age-associated inflammation,…

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Topics & keywords

Topics

Keywords

Inflammation
Dysbiosis
Immunology
Tumor necrosis factor alpha
Biology
Cytokine
Macrophage
Systemic inflammation

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