Nationwide Surveillance of Clinical Carbapenem-resistant Enterobacteriaceae (CRE) Strains in China

The increasing incidence of carbapenem-resistant Enterobacteriaceae (CRE) -mediated hospital infections in China prompted a need to investigate the genetic basis of emergence of such strains. A nationwide survey was conducted in China covering a total of 1105 CRE strains collected from 25 geographical locales with results showing that acquisition of two carbapenemase genes, bla KPC-2 and bla NDM , was responsible for phenotypic resistance in 90% of the CRE strains tested (58% and 32% respectively), among which several major strain types, such as ST11 of K. pneumoniae and ST131/ST167 of E. coli, were identified, suggesting that dissemination of specific resistant clones is mainly responsible for emergence of…

• AU
  Anhui University
• NM
  Ningxia Medical University
• HN
  Hangzhou Normal University
• TM
  Tianjin Medical University
• HH
  Huashan Hospital
• XH
  Xiangya Hospital, Central South University