articleStem Cells Translational MedicineApr 28, 2017GOLD OA

Mesenchymal Stem Cells: Time to Change the Name!

AIArnold I. Caplan

Case Western Reserve University

Indexed incrossrefdoaj

Abstract

Summary Mesenchymal stem cells (MSCs) were officially named more than 25 years ago to represent a class of cells from human and mammalian bone marrow and periosteum that could be isolated and expanded in culture while maintaining their in vitro capacity to be induced to form a variety of mesodermal phenotypes and tissues. The in vitro capacity to form bone, cartilage, fat, etc., became an assay for identifying this class of multipotent cells and around which several companies were formed in the 1990s to medically exploit the regenerative capabilities of MSCs. Today, there are hundreds of clinics and hundreds of clinical trials using human MSCs with very few, if any, focusing on the in vitro multipotential…

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Topics & keywords

Topics
Keywords
  • Mesenchymal stem cell
  • Stem cell
  • Regenerative medicine
  • Clinical uses of mesenchymal stem cells
  • Medicine
  • Bone marrow
  • Adult stem cell
  • Stem cell transplantation for articular cartilage repair
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