Adenovirus-mediated gene delivery: Potential applications for gene and cell-based therapies in the new era of personalized medicine

Gene therapies. There has been a long-lasting interest in using viral vectors, especially adenoviral vectors, to deliver therapeutic genes for the past two decades. Among all currently available viral vectors, adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types. The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development. In fact, among over 2,000 gene therapy clinical trials approved worldwide since 1989, a significant portion of the trials have utilized adenoviral vectors. This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors, including adenoviral…

• UD
  U.S. Department of Defense

  Award: OR130096
• SR
  Scoliosis Research Society
• UO
  University of Chicago

  Award: P30CA014599
• MO
  Ministry of Science and Technology of the People's Republic of China

  Award: 2011CB707906
• CS
  China Scholarship Council
• NI
  National Institutes of Health

  Awards: DE020140, AT004418
• NK
  National Key Research and Development Program of China
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases
• NC
  National Center for Advancing Translational Sciences

  Award: UL1 TR000430