Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure
State Key Laboratory of Pollution Control and Resource Reuse · Nanjing University
Abstract
Microplastics (MPs) are a significant environmental health issue and increasingly greater source of concern. MPs have been detected in oceans, rivers, sediments, sewages, soil and even table salts. MPs exposure on marine organisms and humans has been documented, but information about the toxicity of MPs in mammal is limited. Here we used fluorescent and pristine polystyrene microplastics (PS-MPs) particles with two diameters (5 μm and 20 μm) to investigate the tissue distribution, accumulation, and tissue-specific health risk of MPs in mice. Results indicated that MPs accumulated in liver, kidney and gut, with a tissue-accumulation kinetics and distribution pattern that was strongly depended on the MPs…
Citation impact
- FWCI
- 17.73
- Percentile
- 100%
- References
- 50
Authors
4- YDYongfeng DengCorresponding
State Key Laboratory of Pollution Control and Resource Reuse, Nanjing University
- YZYan Zhang
State Key Laboratory of Pollution Control and Resource Reuse, Nanjing University
- BLBernardo Lemos
- HRHongqiang Ren
State Key Laboratory of Pollution Control and Resource Reuse, Nanjing University
Topics & keywords
- Microplastics
- Toxicity
- Tissue distribution
- Biomarker
- Oxidative stress
- Biology
- Distribution (mathematics)
- Physiology
- Life below water