Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update
Union Hospital · Huazhong University of Science and Technology
Abstract
Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by the cascades of signaling pathway, termed classic and trans-signaling. Besides playing several important physiological roles, dysregulated IL-6 has been demonstrated to underlie a number of autoimmune and inflammatory diseases, metabolic abnormalities, and malignancies. This review provides an overview of basic concept of IL-6 signaling pathway as well as the interplay between IL-6 and renal-resident cells,…
Citation impact
- FWCI
- 12.67
- Percentile
- 100%
- References
- 161
Authors
3Topics & keywords
- Lupus nephritis
- Signal transduction
- Immunology
- Cytokine
- Diabetic nephropathy
- Immune system
- Nephropathy
- Systemic lupus erythematosus
- Reduced inequalities