Inhaled Nanoparticles Accumulate at Sites of Vascular Disease

The development of engineered nanomaterials is growing exponentially, despite concerns over their potential similarities to environmental nanoparticles that are associated with significant cardiorespiratory morbidity and mortality. The mechanisms through which inhalation of nanoparticles could trigger acute cardiovascular events are emerging, but a fundamental unanswered question remains: Do inhaled nanoparticles translocate from the lung in man and directly contribute to the pathogenesis of cardiovascular disease? In complementary clinical and experimental studies, we used gold nanoparticles to evaluate particle translocation, permitting detection by high-resolution inductively coupled mass spectrometry and…

• WT
  Wellcome Trust

  Awards: CH/09/002, WT103782AIA
• BH
  British Heart Foundation

  Awards: CH/09/002, RG/10/9/28286, PG/10/042/28388, PG/12/8/29371, SP/15/8/31575, WT103782AIA, FS/16/14/32023
• DO
  Department of Health and Social Care

  Award: PR-NT-0208-10025
• CF
  Colt Foundation

  Awards: 202111, CF/07/11
• MV
  Ministerie van Infrastructuur en Milieu

  Award: M/630196