The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases
Indiana University – Purdue University Indianapolis · Indiana University Health
Abstract
Il1rl1 (also known as ST2) is a member of the IL-1 superfamily, and its only known ligand is IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a decoy receptor, sequesters free IL-33, and does not signal, and a membrane-bound form (ST2), which activates the MyD88/NF-κB signaling pathway to enhance mast cell, Th2, regulatory T cell (Treg), and innate lymphoid cell type 2 functions. sST2 levels are increased in patients with active inflammatory bowel disease, acute cardiac and small bowel transplant allograft rejection, colon and gastric cancers, gut mucosal damage during viral infection, pulmonary disease, heart disease, and graft-versus-host disease. Recently, sST2 has…
Citation impact
- FWCI
- 20.07
- Percentile
- 100%
- References
- 207
Authors
2Topics & keywords
- Innate lymphoid cell
- Immunology
- Interleukin 33
- Inflammation
- Immune system
- Inflammatory bowel disease
- Signal transduction
- Innate immune system
- Good health and well-being