articleNature CommunicationsApr 27, 2017GOLD OA

Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer

JLJulienne L. CarstensPCPedro Corrêa de SampaioDYDalu YangSBSouptik BaruaHWHuamin Wang

The University of Texas MD Anderson Cancer Center · Rice University · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Abstract The exact nature and dynamics of pancreatic ductal adenocarcinoma (PDAC) immune composition remains largely unknown. Desmoplasia is suggested to polarize PDAC immunity. Therefore, a comprehensive evaluation of the composition and distribution of desmoplastic elements and T-cell infiltration is necessary to delineate their roles. Here we develop a novel computational imaging technology for the simultaneous evaluation of eight distinct markers, allowing for spatial analysis of distinct populations within the same section. We report a heterogeneous population of infiltrating T lymphocytes. Spatial distribution of cytotoxic T cells in proximity to cancer cells correlates with increased overall patient…

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630
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Authors

9

Topics & keywords

Topics
Keywords
  • Desmoplasia
  • Stromal cell
  • Pancreatic cancer
  • Immune system
  • Infiltration (HVAC)
  • Cytotoxic T cell
  • Population
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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