reviewEuropean Journal of ImmunologyMay 5, 2017BRONZE OA

CD69: from activation marker to metabolic gatekeeper

DCDanay CibriánFSFrancisco Sánchez‐Madrid

Instituto de Salud Carlos III · Spanish National Centre for Cardiovascular Research · +4 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

CD69 is a membrane-bound, type II C-lectin receptor. It is a classical early marker of lymphocyte activation due to its rapid appearance on the surface of the plasma membrane after stimulation. CD69 is expressed by several subsets of tissue resident immune cells, including resident memory T (TRM) cells and gamma delta (γδ) T cells, and is therefore considered a marker of tissue retention. Recent evidence has revealed that CD69 regulates some specific functions of selected T-cell subsets, determining the migration-retention ratio as well as the acquisition of effector or regulatory phenotypes. Specifically, CD69 regulates the differentiation of regulatory T (Treg) cells as well as the secretion of IFN-γ, IL-17,…

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938
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100%
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64
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Authors

2

Topics & keywords

Topics
Keywords
  • Biology
  • CD69
  • Cell biology
  • Immune system
  • Effector
  • Lectin
  • Receptor
  • T cell
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