Retrospective analysis of natural products provides insights for future discovery trends
University of California, Santa Cruz · Scripps Institution of Oceanography · +3 more institutions
Abstract
Understanding of the capacity of the natural world to produce secondary metabolites is important to a broad range of fields, including drug discovery, ecology, biosynthesis, and chemical biology, among others. Both the absolute number and the rate of discovery of natural products have increased significantly in recent years. However, there is a perception and concern that the fundamental novelty of these discoveries is decreasing relative to previously known natural products. This study presents a quantitative examination of the field from the perspective of both number of compounds and compound novelty using a dataset of all published microbial and marine-derived natural products. This analysis aimed to…
Citation impact
- FWCI
- 42.26
- Percentile
- 100%
- References
- 43
Authors
5- CRCameron R. PyeCorresponding
University of California, Santa Cruz
- MJMatthew J. Bertin
Scripps Institution of Oceanography, University of California San Diego, University of Montana
- RSR. Scott Lokey
University of California, Santa Cruz
- WHWilliam H. Gerwick
Scripps Institution of Oceanography, University of California San Diego, University of Montana
- RGRoger G. Linington
Simon Fraser University
Topics & keywords
- Natural (archaeology)
- Novelty
- Natural product
- Chemical space
- Relevance (law)
- Space (punctuation)
- Function (biology)
- Data science