The KEAP1–NRF2 System in Cancer
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Abstract
Cancer cells first adapt to the microenvironment and then propagate. Mutations in tumor suppressor genes or oncogenes are frequently found in cancer cells. Comprehensive genomic analyses have identified somatic mutations and other alterations in the KEAP1 or NRF2 genes and in well-known tumor suppressor genes or oncogenes, such as TP53, CDKN2A, PTEN, and PIK3CA, in various types of cancer. Aberrant NRF2 activation in cancer cells occurs through somatic mutations in the KEAP1 or NRF2 gene as well as through other mechanisms that disrupt the binding of KEAP1 to NRF2. Unregulated NRF2 confers on cancer cells high-level resistance to anti-cancer drugs and reactive oxygen species (ROS) and directs cancer cells…
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Authors
2Topics & keywords
Topics
Keywords
- Cancer
- Cancer cell
- Cancer research
- KEAP1
- Somatic cell
- CDKN2A
- Reprogramming
- Suppressor
UN Sustainable Development Goals
- Good health and well-being
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Funding
- NFNaito Foundation
- TSTakeda Science Foundation
- JAJapan Agency for Medical Research and DevelopmentAward: CREST
- MOMinistry of Education, Culture, Sports, Science and TechnologyAwards: 26111002, CREST
- KMKato Memorial Bioscience Foundation
- MFMitsubishi Foundation
- WFWaksman Foundation of Japan
- JSJapan Society for the Promotion of ScienceAwards: 15H02507, 26460384, 15KK0325, 26111002, 24249015, CREST
- CRCore Research for Evolutional Science and Technology