Dental Enamel Formation and Implications for Oral Health and Disease
University of North Carolina at Chapel Hill · University of Southern California · +2 more institutions
Abstract
Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate species and provides maximum durability that allows teeth to function as weapons and/or tools as well as for food processing. Enamel development and mineralization is an intricate process tightly regulated by cells of the enamel organ called ameloblasts. These heavily polarized cells form a monolayer around the developing enamel tissue and move as a single forming front in specified directions as they lay down a proteinaceous matrix that serves as a template for crystal growth. Ameloblasts maintain intercellular connections creating a semi-permeable barrier that at one end (basal/proximal) receives nutrients and ions from…
Citation impact
- FWCI
- 19.26
- Percentile
- 100%
- References
- 693
Authors
4- RSRodrigo S. LacruzCorresponding
University of North Carolina at Chapel Hill, University of Southern California, University of California, San Francisco, New York University
- SHStefan Habelitz
University of North Carolina at Chapel Hill, University of Southern California, University of California, San Francisco, New York University
- JTJ. Timothy Wright
University of North Carolina at Chapel Hill, University of Southern California, University of California, San Francisco, New York University
- MLMichael L. Paine
University of North Carolina at Chapel Hill, University of Southern California, University of California, San Francisco, New York University
Topics & keywords
- Ameloblast
- Enamel paint
- Mineralized tissues
- Amelogenin
- Enamel organ
- Cell biology
- Amelogenesis
- Tooth enamel
- Zero hunger