H 2 O 2 -responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay

Significance Hydrogen peroxide is closely associated with many important physiological and pathological events. Herein, we develop a liposomal nanoprobe for in vivo H 2 O 2 -responsive chromogenic assay, which is highly specific and sensitive to H 2 O 2 . Using such a nanoprobe, photoacoustic imaging of H 2 O 2 -related inflammation processes in mice induced by either LPS or bacteria is realized. Meanwhile, such a nanoprobe, by reacting with endogenous H 2 O 2 produced by tumor cells, allows sensitive photoacoustic imaging of early-stage small tumors and orthotopic brain glioma and even enables accurate differentiation of metastatic sentinel lymph nodes from nonmetastatic ones. Furthermore, owing to its H 2 O…

• NN
  National Natural Science Foundation of China

  Award: 51525203
• MO
  Ministry of Education of the People's Republic of China

  Award: 111 Project
• MO
  Ministry of Science and Technology of the People's Republic of China

  Award: 2016YFA0201200
• PA
  Priority Academic Program Development of Jiangsu Higher Education Institutions

  Award: 111 Project
• CI
  Collaborative Innovation Center of Suzhou Nano Science and Technology
• HE
  Higher Education Discipline Innovation Project
• NS
  National Science and Technology Major Project