articleBloodMay 8, 2017BRONZE OA

Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly

FZFlorian ZinkSSSimon StaceyGLGudmundur L. NorddahlMLMichael L. FriggeÓÞÓlafur Þ. Magnússon

deCODE Genetics (Iceland) · Reykjavík University · +3 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Key Points Whole-genome sequencing of 11 262 Icelanders reveals that clonal hematopoiesis is very common in the elderly. Somatic mutation of some genes is strongly associated with clonal hematopoiesis, but in most cases, no driver mutations were evident.

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Topics & keywords

Topics
Keywords
  • Biology
  • Mutation
  • Genetics
  • Haematopoiesis
  • Somatic cell
  • Whole genome sequencing
  • Gene
  • Genome
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