Simultaneous modification of three homoeologs of  Ta EDR 1  by genome editing enhances powdery mildew resistance in wheat

Zhang, Yunwei; Bai, Yang; Wu, Guangheng; Zou, Shenghao; Chen, Yongfang; Gao, Caixia; Tang, Dingzhong

doi:10.1111/tpj.13599

articleThe Plant JournalMay 14, 2017BRONZE OA

Simultaneous modification of three homoeologs of Ta EDR 1 by genome editing enhances powdery mildew resistance in wheat

YZYunwei Zhang YBYang Bai GWGuangheng Wu SZShenghao Zou YCYongfang Chen

Chinese Academy of Sciences · Institute of Genetics and Developmental Biology · +3 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Wheat (Triticum aestivum L.) incurs significant yield losses from powdery mildew, a major fungal disease caused by Blumeria graminis f. sp. tritici (Bgt). enhanced disease resistance1 (EDR1) plays a negative role in the defense response against powdery mildew in Arabidopsis thaliana; however, the edr1 mutant does not show constitutively activated defense responses. This makes EDR1 an ideal target for approaches using new genome-editing tools to improve resistance to powdery mildew. We cloned TaEDR1 from hexaploid wheat and found high similarity among the three homoeologs of EDR1. Knock-down of TaEDR1 by virus-induced gene silencing or RNA interference enhanced resistance to powdery mildew, indicating that…

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Topics & keywords

Topics

Keywords

Powdery mildew
Blumeria graminis
Biology
Germplasm
Plant disease resistance
Mildew
Genetics
Gene

UN Sustainable Development Goals

Good health and well-being

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