In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy
Harvard University · Massachusetts General Hospital · +2 more institutions
Indexed incrossrefpubmed
Abstract
T cells and enhances immunotherapy-induced tumor regression in mice. These investigations yield insight into aPD-1 target engagement in vivo and identify specific Fc/FcγR interactions that can be modulated to improve checkpoint blockade therapy.
Citation impact
644
total citations
- FWCI
- 26.39
- Percentile
- 100%
- References
- 55
Citations per year
Authors
12- SPSean P. ArlauckasCorresponding
Harvard University, Massachusetts General Hospital, Center for Systems Biology
- CGChristopher GarrisCorresponding
Harvard University, Massachusetts General Hospital, Center for Systems Biology
- RHRainer H. Köhler
Massachusetts General Hospital, Center for Systems Biology
- MKMaya Kitaoka
Massachusetts General Hospital
- MFMichael F. Cuccarese
Massachusetts General Hospital, Center for Systems Biology
Topics & keywords
Topics
Keywords
- In vivo
- Antibody therapy
- Macrophage
- Cancer research
- Antibody
- Immunotherapy
- CD8
- Immune system
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