Artificial Biocatalytic Linear Cascades for Preparation of Organic Molecules
University of Graz · BioTechMed-Graz · +1 more institution
Abstract
The review compiles artificial cascades involving enzymes with a focus on the last 10 years. A cascade is defined as the combination of at least two reaction steps in a single reaction vessel without isolation of the intermediates, whereby at least one step is catalyzed by an enzyme. Additionally, cascades performed in vivo and in vitro are discussed separately, whereby in vivo cascades are defined here as cascades relying on cofactor recycling by the metabolism or on a metabolite from the living organism. The review introduces a systematic classification of the cascades according to the number of enzymes in the linear sequence and differentiates between cascades involving exclusively enzymes and combinations…
Citation impact
- FWCI
- 27.81
- Percentile
- 100%
- References
- 425
Authors
4- JHJoerg H. SchrittwieserCorresponding
University of Graz, BioTechMed-Graz
- SVStefan Velikogne
University of Graz, Austrian Centre of Industrial Biotechnology (Austria)
- MHMélanie Hall
University of Graz, BioTechMed-Graz
- WKWolfgang Kroutil
University of Graz, BioTechMed-Graz, Austrian Centre of Industrial Biotechnology (Austria)
Topics & keywords
- Chemistry
- Cascade
- Enzyme
- Cascade reaction
- In vivo
- Combinatorial chemistry
- Catalysis
- Computational biology